VIM proteins regulate transcription exclusively through the MET1 cytosine methylation pathway
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چکیده
منابع مشابه
VIM proteins regulate transcription exclusively through the MET1 cytosine methylation pathway
In Arabidopsis, variant in methylation (VIM) proteins are required for the maintenance of DNA methylation in the CpG dinucleotide context. VIM1 acts as a cofactor of DNA methyltransferase 1 (MET1), although the mechanism for this co-regulation remains unclear. In this study, we used RNA-seq analysis to profile the transcriptomes of vim1, vim1 vim2 vim3, and met1 null mutants. Consistent with pr...
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We describe the isolation and characterization of two missense mutations in the cytosine-DNA-methyltransferase gene, MET1, from the flowering plant Arabidopsis thaliana. Both missense mutations, which affect the catalytic domain of the protein, led to a global reduction of cytosine methylation throughout the genome. Surprisingly, the met1-2 allele, with the weaker DNA hypomethylation phenotype,...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2014
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.28906